Wnt6 marks sites of epithelial transformations in the chick embryo

نویسندگان

  • Frank R. Schubert
  • Roy C. Mootoosamy
  • Esther H. Walters
  • Anthony Graham
  • Loretta Tumiotto
  • Andrea E. Münsterberg
  • Andrew Lumsden
  • Susanne Dietrich
چکیده

In a screen for Wnt genes executing the patterning function of the vertebrate surface ectoderm, we have isolated a novel chick Wnt gene, chick Wnt6. This gene encodes the first pan-epidermal Wnt signalling molecule. Further sites of expression are the boundary of the early neural plate and surface ectoderm, the roof of mesencephalon, pretectum and dorsal thalamus, the differentiating heart, and the otic vesicle. The precise sites of Wnt6 expression coincide with crucial changes in tissue architecture, namely epithelial remodelling and epithelial-mesenchymal transformation (EMT). Moreover, the expression of Wnt6 is closely associated with areas of Bmp signalling.

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عنوان ژورنال:
  • Mechanisms of Development

دوره 114  شماره 

صفحات  -

تاریخ انتشار 2002